NEWS
invivoPKfit 2.0.2 (2025-08-26)
- Minor bug fix for adjusting rate constants after fitting to standard "1/hour".
- Improved
pk object organization and CLI message outputs.
- Externalized parallel processing for fitting with
mirai and purrr 1.1.0.
Now, users should set the number of processes through those interfaces if
parallel or distributed computing is desired.
- Setting data, error, NCA, sd, and LOQ groups now uses unquoted data variable names,
the latter two have their own separate
pkproto object setups: stat_sd_group() and stat_loq_group().
- Parameter starts and and estimates are stored as singular values in a
list-column,
which allows character vector constant parameters for calls to more complex PBTK models,
see model_httk_gas_pbtk.
- Users may now set specific parameters to optimize and specific start values using the new functions
set_params_optimize() and set_params_starts().
- Updated
cvt object to align with latest CvTdb release.
invivoPKfit 2.0.1 (2025-03-24)
- Ensured only optimized parameters will be used when calculating AIC. This is really
only a concern when using models that hold many of the total parameters constant.
- Added a new feature allowing users to calculate log-likelihood from predictions
generated outside invivoPKfit.
- Updated documentation and cleaned up vignettes.
invivoPKfit 2.0.0 (2025-01-09)
- Initial CRAN submission.
- Redesigned package to an S3 object-oriented approach with some ggplot2-like syntax.
- Re-factored function/method code to ensure the code base is more legible to future contributors.
- Implemented messages that save and update data processing "status".
- Parallel processing parameter optimization was added as an option to take advantage of multi-processing cores.
- Included more chemical records than previously published in the
cvt object, represented a processed portion of the CvTdb database.